Biology:TBPL1
 Generic protein structure example |
TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.[1][2][3][4]
Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.[4]
Interactions
TBPL1 has been shown to interact with GTF2A1.[5][6]
References
- ↑ "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochemical and Biophysical Research Communications 255 (1): 137–42. Feb 1999. doi:10.1006/bbrc.1999.0159. PMID 10082669.
- ↑ "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proceedings of the National Academy of Sciences of the United States of America 96 (9): 4791–6. Apr 1999. doi:10.1073/pnas.96.9.4791. PMID 10220372. Bibcode: 1999PNAS...96.4791R.
- ↑ "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Molecular and Cellular Biology 25 (7): 2632–43. Apr 2005. doi:10.1128/MCB.25.7.2632-2643.2005. PMID 15767669.
- ↑ 4.0 4.1 "Entrez Gene: TBPL1 TBP-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9519.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13720–5. Nov 1999. doi:10.1073/pnas.96.24.13720. PMID 10570139. Bibcode: 1999PNAS...9613720T.
Further reading
- "Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor". Nucleic Acids Research 27 (3): 750–5. Feb 1999. doi:10.1093/nar/27.3.750. PMID 9889269.
- "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13720–5. Nov 1999. doi:10.1073/pnas.96.24.13720. PMID 10570139. Bibcode: 1999PNAS...9613720T.
- "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids". Development 129 (4): 945–55. Feb 2002. doi:10.1242/dev.129.4.945. PMID 11861477.
- "Cell-specific nucleolar localization of TBP-related factor 2". Molecular Biology of the Cell 15 (10): 4356–68. Oct 2004. doi:10.1091/mbc.E04-02-0138. PMID 15269281.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
External links
- TBPL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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