Biology:GTF2A1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.[1][2]
Interactions
GTF2A1 has been shown to interact with TATA binding protein[3][4][5][6][7] and TBPL1.[8][9]
See also
- Transcription Factor II A
References
- ↑ "A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA". Genes & Development 7 (11): 2220–34. Nov 1993. doi:10.1101/gad.7.11.2220. PMID 8224848.
- ↑ "Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2957.
- ↑ "Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription". Proceedings of the National Academy of Sciences of the United States of America 92 (8): 3313–7. Apr 1995. doi:10.1073/pnas.92.8.3313. PMID 7724559. Bibcode: 1995PNAS...92.3313D.
- ↑ "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II". The Journal of Biological Chemistry 276 (42): 38652–7. Oct 2001. doi:10.1074/jbc.M106422200. PMID 11509574.
- ↑ "Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding". The Journal of Biological Chemistry 273 (23): 14293–300. Jun 1998. doi:10.1074/jbc.273.23.14293. PMID 9603936.
- ↑ "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity". The Journal of Biological Chemistry 276 (19): 15886–92. May 2001. doi:10.1074/jbc.M009385200. PMID 11278496.
- ↑ "Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription". Genes & Development 8 (19): 2336–48. Oct 1994. doi:10.1101/gad.8.19.2336. PMID 7958900.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13720–5. Nov 1999. doi:10.1073/pnas.96.24.13720. PMID 10570139. Bibcode: 1999PNAS...9613720T.
Further reading
- "Cloning of a human gene encoding the general transcription initiation factor IIB". Nature 352 (6337): 689–95. Aug 1991. doi:10.1038/352689a0. PMID 1876184. Bibcode: 1991Natur.352..689H.
- "Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription". Proceedings of the National Academy of Sciences of the United States of America 92 (8): 3313–7. Apr 1995. doi:10.1073/pnas.92.8.3313. PMID 7724559. Bibcode: 1995PNAS...92.3313D.
- "Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription". Genes & Development 8 (19): 2324–35. Oct 1994. doi:10.1101/gad.8.19.2324. PMID 7958899.
- "Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription". Genes & Development 8 (19): 2336–48. Oct 1994. doi:10.1101/gad.8.19.2336. PMID 7958900.
- "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein". The Journal of Biological Chemistry 269 (25): 17136–40. Jun 1994. doi:10.1016/S0021-9258(17)32531-0. PMID 8006019.
- "Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription". Genes & Development 7 (11): 2246–57. Nov 1993. doi:10.1101/gad.7.11.2246. PMID 8224850.
- "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex". Proceedings of the National Academy of Sciences of the United States of America 93 (3): 1119–24. Feb 1996. doi:10.1073/pnas.93.3.1119. PMID 8577725. Bibcode: 1996PNAS...93.1119T.
- "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". Journal of Virology 70 (8): 5503–10. Aug 1996. doi:10.1128/JVI.70.8.5503-5510.1996. PMID 8764062.
- "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. Oct 1996. doi:10.1126/science.274.5287.605. PMID 8849451. Bibcode: 1996Sci...274..605Z.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding". The Journal of Biological Chemistry 273 (23): 14293–300. Jun 1998. doi:10.1074/jbc.273.23.14293. PMID 9603936.
- "An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription". Proceedings of the National Academy of Sciences of the United States of America 95 (12): 6722–7. Jun 1998. doi:10.1073/pnas.95.12.6722. PMID 9618479. Bibcode: 1998PNAS...95.6722Y.
- "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". The Journal of Biological Chemistry 273 (47): 30933–8. Nov 1998. doi:10.1074/jbc.273.47.30933. PMID 9812988.
- "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". The Journal of Biological Chemistry 274 (25): 18040–8. Jun 1999. doi:10.1074/jbc.274.25.18040. PMID 10364255.
- "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Molecular and Cellular Biology 19 (9): 6323–32. Sep 1999. doi:10.1128/mcb.19.9.6323. PMID 10454579.
- "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". The Journal of Biological Chemistry 274 (48): 34283–93. Nov 1999. doi:10.1074/jbc.274.48.34283. PMID 10567404.
- "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13720–5. Nov 1999. doi:10.1073/pnas.96.24.13720. PMID 10570139. Bibcode: 1999PNAS...9613720T.
- "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity". The Journal of Biological Chemistry 276 (19): 15886–92. May 2001. doi:10.1074/jbc.M009385200. PMID 11278496.
- "p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction". Molecular and Cellular Biology 21 (11): 3652–61. Jun 2001. doi:10.1128/MCB.21.11.3652-3661.2001. PMID 11340159.
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