Biology:Nur
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Short description: Family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance.
Nur (nuclear receptor subfamily 4) is a family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance. In 2006, members of the NR4A family were implicated in the control of skeletal muscle metabolism.[1][2]
Three members have been identified in humans:[3][4]
- nerve Growth factor IB (Nur77, or NR4A1),
- nuclear receptor related 1 protein (Nurr1, or NR4A2), and
- neuron-derived orphan receptor 1 (Nor-1, or NR4A3).
References
- ↑ "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. 2006. doi:10.1210/en.2006-0447. PMID 16901967.
- ↑ "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. 2008. doi:10.1210/en.2007-1202. PMID 18325999.
- ↑ "The NR4A subgroup: immediate early response genes with pleiotropic physiological roles". Nucl Recept Signal 4: e002. 2006. doi:10.1621/nrs.04002. PMID 16604165.
- ↑ "Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action". J. Pharmacol. Exp. Ther. 313 (1): 460–73. 2005. doi:10.1124/jpet.104.080184. PMID 15615863. https://corpus.ulaval.ca/jspui/bitstream/20.500.11794/17025/1/induction.pdf.
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