Biology:PEG3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[1][2] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[3] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[4]
Interactions
PEG3 has been shown to interact with SIAH2[5] and SIAH1.[5]
References
- ↑ "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res 7 (5): 532–40. August 1997. doi:10.1101/gr.7.5.532. PMID 9149948.
- ↑ "Entrez Gene: PEG3 paternally expressed 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178.
- ↑ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE 8 (12): e83359. doi:10.1371/journal.pone.0083359. PMID 24391757. Bibcode: 2013PLoSO...883359K.
- ↑ "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene 512 (2): 314–320. January 2013. doi:10.1016/j.gene.2012.10.005. PMID 23078764.
- ↑ 5.0 5.1 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (5): 2105–10. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMID 10681424. Bibcode: 2000PNAS...97.2105R.
Further reading
- "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.". Nat. Genet. 18 (3): 287–91. 1998. doi:10.1038/ng0398-287. PMID 9500555.
- "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. 2000. doi:10.1073/pnas.040378897. PMID 10681424. Bibcode: 2000PNAS...97.2105R.
- "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).". Genomics 64 (1): 114–8. 2000. doi:10.1006/geno.1999.6112. PMID 10708526. https://zenodo.org/record/1229800.
- "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line.". Genes Cells 6 (3): 237–47. 2001. doi:10.1046/j.1365-2443.2001.00412.x. PMID 11260267.
- "Paternal monoallelic expression of PEG3 in the human placenta.". Hum. Mol. Genet. 10 (10): 1093–100. 2001. doi:10.1093/hmg/10.10.1093. PMID 11331620.
- "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. 2002. doi:10.1002/jcb.1257. PMID 11746496. https://zenodo.org/record/1229223.
- "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death.". J. Biol. Chem. 277 (25): 23000–7. 2002. doi:10.1074/jbc.M201907200. PMID 11943780.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.". Cell Cycle 4 (6): 806–11. 2006. doi:10.4161/cc.4.6.1716. PMID 15908796.
- "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.". Gynecol. Oncol. 99 (1): 126–34. 2005. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
- "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells.". Biol. Cell 98 (4): 253–63. 2006. doi:10.1042/BC20050041. PMID 16159311.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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