Biology:PLAG1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Zinc finger protein PLAG1 is a protein that in humans is encoded by the PLAG1 gene.[1][2]

Function

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.[2]

Interactions

PLAG1 has been shown to interact with Karyopherin alpha 2.[3]

References

  1. ↑ "A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands". Genomics 43 (3): 349–58. Nov 1997. doi:10.1006/geno.1997.4819. PMID 9268638. 
  2. ↑ 2.0 2.1 "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5324. 
  3. ↑ "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. May 2002. doi:10.1074/jbc.M112112200. PMID 11882654. 

Further reading

  • "PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review)". Int. J. Oncol. 30 (4): 765–74. 2007. doi:10.3892/ijo.30.4.765. PMID 17332914. 
  • "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations". Nat. Genet. 15 (2): 170–4. 1997. doi:10.1038/ng0297-170. PMID 9020842. 
  • "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene 16 (11): 1409–16. 1998. doi:10.1038/sj.onc.1201660. PMID 9525740. 
  • "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. 1998. doi:10.1074/jbc.273.36.23026. PMID 9722527. 
  • "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene". Cancer Res. 59 (4): 918–23. 1999. PMID 10029085. 
  • "PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II". Cancer Res. 60 (1): 106–13. 2000. PMID 10646861. 
  • "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. 2002. doi:10.1074/jbc.M112112200. PMID 11882654. 
  • "The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities". Cancer Res. 62 (5): 1510–7. 2002. PMID 11888928. 
  • "Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas". Int. J. Oncol. 20 (4): 713–6. 2002. doi:10.3892/ijo.20.4.713. PMID 11894114. 
  • "Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma". Genes Chromosomes Cancer 39 (2): 126–37. 2004. doi:10.1002/gcc.10307. PMID 14695992. 
  • "Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation". J. Biol. Chem. 279 (34): 36121–31. 2004. doi:10.1074/jbc.M401753200. PMID 15208321. 
  • "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
  • "Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification". Cancer Genet. Cytogenet. 152 (2): 124–8. 2004. doi:10.1016/j.cancergencyto.2003.12.001. PMID 15262430. 
  • "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood 105 (7): 2900–7. 2005. doi:10.1182/blood-2004-09-3630. PMID 15585652. 
  • "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement". Cancer Genet. Cytogenet. 156 (2): 183–4. 2005. doi:10.1016/j.cancergencyto.2004.04.017. PMID 15642402. 
  • "PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry". Mod. Pathol. 18 (8): 1048–55. 2005. doi:10.1038/modpathol.3800386. PMID 15920557. 
  • "Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression". Cancer Res. 65 (11): 4544–53. 2005. doi:10.1158/0008-5472.CAN-04-4041. PMID 15930271. 
  • "Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice". Int. J. Cancer 118 (3): 643–8. 2006. doi:10.1002/ijc.21400. PMID 16108035. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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