Biology:Sterol regulatory element-binding protein 2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.

Function

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis.

Interactions

SREBF2 has been shown to interact with INSIG1 and CREB-binding protein.

See also

• Sterol regulatory element-binding protein

Further reading

• "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin". Genes & Development 15 (15): 1873–8. Aug 2001. doi:10.1101/gad.916601. PMID 11485982. 
• "The potential role of sterol regulatory element binding protein transcription factors in renal injury". Journal of Renal Nutrition 17 (1): 62–5. Jan 2007. doi:10.1053/j.jrn.2006.10.009. PMID 17198935. 
• "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics 25 (3): 667–73. Feb 1995. doi:10.1016/0888-7543(95)80009-B. PMID 7759101. 
• "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell 75 (1): 187–97. Oct 1993. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897. 
• "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis". The EMBO Journal 15 (5): 1012–20. Mar 1996. doi:10.1002/j.1460-2075.1996.tb00438.x. PMID 8605870. 
• "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane". The Journal of Biological Chemistry 271 (17): 10379–84. Apr 1996. doi:10.1074/jbc.271.17.10379. PMID 8626610. 
• "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins". Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5437–42. May 1996. doi:10.1073/pnas.93.11.5437. PMID 8643593. Bibcode: 1996PNAS...93.5437P. 
• "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2". The Journal of Biological Chemistry 271 (43): 26461–4. Oct 1996. doi:10.1074/jbc.271.43.26461. PMID 8900111. 
• "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development 10 (22): 2903–11. Nov 1996. doi:10.1101/gad.10.22.2903. PMID 8918891. 
• "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)". Genomics 40 (1): 31–40. Feb 1997. doi:10.1006/geno.1996.4525. PMID 9070916. 
• "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2". The Journal of Biological Chemistry 272 (19): 12778–85. May 1997. doi:10.1074/jbc.272.19.12778. PMID 9139737. 
• "Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis". Journal of Lipid Research 39 (2): 412–22. Feb 1998. doi:10.1016/S0022-2275(20)33902-X. PMID 9508001. 
• "DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter". Nucleic Acids Research 27 (4): 1104–17. Feb 1999. doi:10.1093/nar/27.4.1104. PMID 9927745. 
• "Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization". Proceedings of the National Academy of Sciences of the United States of America 96 (4): 1321–6. Feb 1999. doi:10.1073/pnas.96.4.1321. PMID 9990022. Bibcode: 1999PNAS...96.1321S. 
• "Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip". Molecular Biology of the Cell 10 (7): 2221–33. Jul 1999. doi:10.1091/mbc.10.7.2221. PMID 10397761. 
• "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. Dec 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D. 
• "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi". Cell 99 (7): 703–12. Dec 1999. doi:10.1016/S0092-8674(00)81668-2. PMID 10619424. 
• "Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade". Journal of Lipid Research 41 (1): 99–108. Jan 2000. doi:10.1016/S0022-2275(20)32079-4. PMID 10627507. 
• "Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum". The Journal of Biological Chemistry 275 (38): 29881–6. Sep 2000. doi:10.1074/jbc.M005439200. PMID 10896675. 

External links

• SREBF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook SREBP2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.