Biology:ZNF274
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.[1][2]
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.[2]
References
- ↑ "Identification and characterization of human ZNF274 cDNA, which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability". Genomics 65 (1): 75–80. Jun 2000. doi:10.1006/geno.2000.6140. PMID 10777669.
- ↑ 2.0 2.1 "Entrez Gene: ZNF274 zinc finger protein 274". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10782.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Computer sequence analysis of human highly conserved zinc finger modules". DNA Seq. 9 (3): 163–9. 1999. doi:10.3109/10425179809072191. PMID 10520746.
- "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death". EMBO J. 18 (21): 6050–61. 2000. doi:10.1093/emboj/18.21.6050. PMID 10545116.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. 2004. doi:10.1073/pnas.0404089101. PMID 15498874. Bibcode: 2004PNAS..10115724W.
- "The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression". Mol. Cell. Biol. 26 (22): 8623–38. 2007. doi:10.1128/MCB.00487-06. PMID 16954381.
External links
- ZNF274+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook ZNF274
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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