Biology:ING1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3]
Function
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Location on Chromosome 13
ING1 is located near the following genes on Chromosome 13
- CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
- COL4A2: A2 Subunit of type IV collagen
- RAB20: Potential regulator of Connexin 43 trafficking.
- CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2
Interactions
ING1 has been shown to interact with:
- CREB binding protein,[4]
- DMAP1,[5]
- HDAC1,[4][6]
- P53,[7][8]
- PCNA,[9]
- SAP30,[6]
- SIN3A,[6]
- SMARCA4,[6] and
- SMARCC1.[6]
References
- ↑ "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nature Genetics 14 (4): 415–20. Dec 1996. doi:10.1038/ng1296-415. PMID 8944021.
- ↑ "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics 76 (3–4): 176–8. Jul 1997. doi:10.1159/000134539. PMID 9186514.
- ↑ 3.0 3.1 "Entrez Gene: ING1 inhibitor of growth family, member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621.
- ↑ 4.0 4.1 "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry 277 (33): 29832–9. Aug 2002. doi:10.1074/jbc.M200197200. PMID 12015309.
- ↑ "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". The Journal of Biological Chemistry 279 (10): 9539–46. Mar 2004. doi:10.1074/jbc.M311587200. PMID 14665632.
- ↑ 6.0 6.1 6.2 6.3 6.4 "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology 22 (3): 835–48. Feb 2002. doi:10.1128/mcb.22.3.835-848.2002. PMID 11784859.
- ↑ "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Research 62 (17): 4890–3. Sep 2002. PMID 12208736.
- ↑ "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature 391 (6664): 295–8. Jan 1998. doi:10.1038/34675. PMID 9440695. Bibcode: 1998Natur.391..295G.
- ↑ "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science 114 (Pt 19): 3455–62. Oct 2001. doi:10.1242/jcs.114.19.3455. PMID 11682605.
Further reading
- "Biological functions of the ING family tumor suppressors". Cellular and Molecular Life Sciences 61 (19–20): 2597–613. Oct 2004. doi:10.1007/s00018-004-4199-4. PMID 15526165.
- "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis". Cancer Research 57 (7): 1255–8. Apr 1997. PMID 9102209.
- "Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor". Molecular and Cellular Biology 17 (4): 2014–9. Apr 1997. doi:10.1128/mcb.17.4.2014. PMID 9121449.
- "Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34". Somatic Cell and Molecular Genetics 23 (3): 233–6. May 1997. doi:10.1007/BF02721376. PMID 9330636.
- "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature 391 (6664): 295–8. Jan 1998. doi:10.1038/34675. PMID 9440695. Bibcode: 1998Natur.391..295G.
- "Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas". Cancer Research 59 (21): 5521–8. Nov 1999. PMID 10554029.
- "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene". Cancer Research 59 (24): 6197–204. Dec 1999. PMID 10626813.
- "Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions". Genes, Chromosomes & Cancer 27 (3): 319–22. Mar 2000. doi:10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P. PMID 10679922.
- "Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers". Cancer Letters 152 (1): 15–22. Apr 2000. doi:10.1016/S0304-3835(99)00434-6. PMID 10754201.
- "[Genomic organization of the suppressor gene for tumor growth ING1]". Molekuliarnaia Biologiia 34 (2): 263–9. 2000. PMID 10779953.
- "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1". Journal of Human Genetics 45 (3): 177–81. 2000. doi:10.1007/s100380050206. PMID 10807544.
- "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas". Cancer Research 60 (12): 3143–6. Jun 2000. PMID 10866301.
- "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex". The Journal of Biological Chemistry 276 (12): 8734–9. Mar 2001. doi:10.1074/jbc.M007664200. PMID 11118440.
- "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proceedings of the National Academy of Sciences of the United States of America 98 (17): 9671–6. Aug 2001. doi:10.1073/pnas.161151798. PMID 11481424. Bibcode: 2001PNAS...98.9671N.
- "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science 114 (Pt 19): 3455–62. Oct 2001. doi:10.1242/jcs.114.19.3455. PMID 11682605.
- "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology 22 (3): 835–48. Feb 2002. doi:10.1128/MCB.22.3.835-848.2002. PMID 11784859.
- "Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues". Hybridoma and Hybridomics 21 (1): 1–10. Feb 2002. doi:10.1089/15368590252917584. PMID 11991811.
- "Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies". Leukemia Research 26 (7): 631–5. Jul 2002. doi:10.1016/S0145-2126(01)00185-0. PMID 12008079.
External links
- ING1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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