Biology:RBPJ
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.[1][2][3]
RBPJ[4] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[5]
Interactions
RBPJ has been shown to interact with:
References
- ↑ "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics 17 (2): 306–315. August 1993. doi:10.1006/geno.1993.1326. PMID 8406481.
- ↑ "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics 42 (2): 337–341. June 1997. doi:10.1007/BF02766956. PMID 9290259.
- ↑ "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region". https://www.ncbi.nlm.nih.gov/gene/3516.
- ↑ "HGNC: RBPJ Symbol Report". https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/5724.
- ↑ "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology 16 (3): 952–959. March 1996. doi:10.1128/mcb.16.3.952. PMID 8622698.
- ↑ "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry 278 (23): 21232–21239. June 2003. doi:10.1074/jbc.M301567200. PMID 12644465.
- ↑ "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry 272 (17): 11336–11343. April 1997. doi:10.1074/jbc.272.17.11336. PMID 9111040.
- ↑ "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development 104 (1–2): 3–20. June 2001. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
- ↑ "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology 21 (18): 6222–6232. September 2001. doi:10.1128/mcb.21.18.6222-6232.2001. PMID 11509665.
- ↑ "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry 275 (22): 17211–17220. June 2000. doi:10.1074/jbc.M000909200. PMID 10747963.
- ↑ 11.0 11.1 "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology 74 (4): 1939–1947. February 2000. doi:10.1128/jvi.74.4.1939-1947.2000. PMID 10644367.
- ↑ "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 23–28. January 1999. doi:10.1073/pnas.96.1.23. PMID 9874765. Bibcode: 1999PNAS...96...23H.
- ↑ "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology 20 (7): 2400–2410. April 2000. doi:10.1128/mcb.20.7.2400-2410.2000. PMID 10713164.
- ↑ "R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma". eLife 8: e43026. July 2019. doi:10.7554/eLife.43026. PMID 31358114.
- ↑ "Notch-independent RBPJ controls angiogenesis in the adult heart". Nature Communications 7 (1): 12088. June 2016. doi:10.1038/ncomms12088. PMID 27357444. Bibcode: 2016NatCo...712088D.
Further reading
- "V(D)J recombination of immunoglobulin genes". Advances in Biophysics 31: 163–180. 1995. doi:10.1016/0065-227X(95)99390-B. PMID 7625272.
- "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif". Nature 342 (6252): 934–937. 1990. doi:10.1038/342934a0. PMID 2556644.
- "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology 15 (9): 4735–4744. September 1995. doi:10.1128/mcb.15.9.4735. PMID 7651391.
- "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa". Journal of Virology 70 (7): 4228–4236. July 1996. doi:10.1128/JVI.70.7.4228-4236.1996. PMID 8676443.
- "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)". Current Biology 5 (12): 1416–1423. December 1995. doi:10.1016/S0960-9822(95)00279-X. PMID 8749394.
- "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–1830. October 1996. PMID 8895530.
- "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation". Journal of Virology 71 (3): 1938–1945. March 1997. doi:10.1128/JVI.71.3.1938-1945.1997. PMID 9032325.
- "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry 272 (17): 11336–11343. April 1997. doi:10.1074/jbc.272.17.11336. PMID 9111040.
- "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes & Development 12 (15): 2269–2277. August 1998. doi:10.1101/gad.12.15.2269. PMID 9694793.
- "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 23–28. January 1999. doi:10.1073/pnas.96.1.23. PMID 9874765. Bibcode: 1999PNAS...96...23H.
- "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer 83 (4): 456–464. November 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells". Leukemia 14 (1): 84–92. January 2000. doi:10.1038/sj.leu.2401630. PMID 10637481.
- "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". Journal of Virology 74 (7): 3082–3092. April 2000. doi:10.1128/JVI.74.7.3082-3092.2000. PMID 10708423.
- "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology 20 (7): 2400–2410. April 2000. doi:10.1128/MCB.20.7.2400-2410.2000. PMID 10713164.
- "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry 275 (22): 17211–17220. June 2000. doi:10.1074/jbc.M000909200. PMID 10747963.
- "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development 104 (1–2): 3–20. June 2001. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076.
- "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology 21 (18): 6222–6232. September 2001. doi:10.1128/MCB.21.18.6222-6232.2001. PMID 11509665.
External links
- RBPJ+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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