Biology:5-HT1F receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT₁ receptor protein and also denotes the human gene encoding it.

Agonists

• 5-n-Butyryloxy-DMT: >60-fold selectivity versus 5-HT_1E receptor
• BRL-54443 - mixed 5-HT_1E/1F agonist
• Eletriptan - mixed 5-HT_{1B/1D/1E/1F/2B/7} agonist
• LY-334,370 - as well as related benzamides
• LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
• Naratriptan - mixed 5-HT_1B/1D/1F agonist
• Lasmiditan - selective 5-HT_1F agonist, a first-in-class ditan molecule

Antagonists

MLS000756415

See also

• 5-HT₁ receptor
• 5-HT receptor

Further reading

• "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacology Biochemistry and Behavior 71 (4): 533–54. Apr 2002. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546. 
• "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacology & Therapeutics 92 (2–3): 179–212. 2002. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537. 
• "Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus". The Journal of Biological Chemistry 267 (28): 19761–4. Oct 1992. doi:10.1016/S0021-9258(19)88617-9. PMID 1328180. 
• "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America 90 (2): 408–12. Jan 1993. doi:10.1073/pnas.90.2.408. PMID 8380639. Bibcode: 1993PNAS...90..408A. 
• "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America 90 (6): 2184–8. Mar 1993. doi:10.1073/pnas.90.6.2184. PMID 8384716. Bibcode: 1993PNAS...90.2184L. 
• "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics 77 (5): 415–20. Jun 1998. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173. 
• "Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors". The Journal of Biological Chemistry 279 (33): 34614–23. Aug 2004. doi:10.1074/jbc.M404673200. PMID 15190056. 
• "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia". PLOS Genetics 1 (4): e50. Oct 2005. doi:10.1371/journal.pgen.0010050. PMID 16254601. 

External links

• "5-HT_1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2318. 
• Human HTR1F genome location and HTR1F gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.