Biology:PBX1
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Short description: Protein found in humans
 Generic protein structure example |
Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[1] The homologous protein in Drosophila is known as extradenticle, and causes changes in embryonic development.
Function
Mice studies suggest PBX1 is involved in bone generation and skeletal patterning.[2]
Interactions
PBX1 has been shown to interact with:
Fruit fly homolog
The Drosophila melangoster gene called extradenticle encodes a homeodomain protein that is 71% similar to the Pbx1 protein, and is considered homologous to PBX1.[10] extradenticle is a homeodomain transcription factor[11] expressed during embryogenesis and is related to morphological changes and development.[10]
Reduced levels of extradenticle cause segmental transformations, without affecting the functionality or location of homeotic genes. Complete removal of extradenticle both maternally and zygotically leads to alterations from failure of non-extradenticle protein expression.[12]
A monoclonal antibody study of the expression of extradenticle protein in embryonic development found that it is uniformly distributed, as well as excluded from cell nuclei, until gastrulation. During the germ band retraction stage of development, extradenticle protein begins to accumulate in the nuclei of cells in a specific pattern. Proximal areas of wing and leg imaginal discs have extradenticle present in the nucleus, while distal areas only have it in the cytoplasm.[13]
References
- ↑ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5087.
- ↑ "PBX1 PBX homeobox 1 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=5087.
- ↑ "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal 17 (5): 1434–45. Mar 1998. doi:10.1093/emboj/17.5.1434. PMID 9482740.
- ↑ "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell 96 (4): 587–97. Feb 1999. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460.
- ↑ "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development 9 (6): 663–74. Mar 1995. doi:10.1101/gad.9.6.663. PMID 7729685.
- ↑ "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. Apr 1999. doi:10.1128/MCB.19.4.3051. PMID 10082572.
- ↑ "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. Nov 1999. doi:10.1128/MCB.19.11.7577. PMID 10523646.
- ↑ "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. Jul 1999. doi:10.1128/MCB.19.7.5134. PMID 10373562.
- ↑ "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Molecular and Cellular Biology 26 (11): 4111–21. Jun 2006. doi:10.1128/MCB.00222-06. PMID 16705164.
- ↑ 10.0 10.1 Rauskolb, Cordella; Peifer, Mark; Wieschaus, Eric (September 1993). "extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1". Cell 74 (6): 1101–1112. doi:10.1016/0092-8674(93)90731-5. ISSN 0092-8674. PMID 8104703. https://doi.org/10.1016/0092-8674(93)90731-5.
- ↑ Aspland, S.E.; White, R.A. (1997-02-01). "Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila". Development 124 (3): 741–747. doi:10.1242/dev.124.3.741. ISSN 1477-9129. PMID 9043089. https://doi.org/10.1242/dev.124.3.741.
- ↑ Peifer, M.; Wieschaus, E. (1990-07-01). "Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity." (in en). Genes & Development 4 (7): 1209–1223. doi:10.1101/gad.4.7.1209. ISSN 0890-9369. PMID 1976570. http://genesdev.cshlp.org/content/4/7/1209.
- ↑ "Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila". https://journals.biologists.com/dev/article/124/3/741/39722/Nucleocytoplasmic-localisation-of-extradenticle.
Further reading
- "B-cell development fails in the absence of the Pbx1 proto-oncogene". Blood 109 (10): 4191–9. May 2007. doi:10.1182/blood-2006-10-054213. PMID 17244677.
- "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood". European Journal of Endocrinology 146 (2): 129–41. Feb 2002. doi:10.1530/eje.0.1460129. PMID 11834421.
- "The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias". Blood 77 (4): 687–93. Feb 1991. doi:10.1182/blood.V77.4.687.687. PMID 1671560.
- "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Molecular and Cellular Biology 11 (12): 6149–57. Dec 1991. doi:10.1128/mcb.11.12.6149. PMID 1682799.
- "Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor". Cell 60 (4): 535–45. Feb 1990. doi:10.1016/0092-8674(90)90657-Z. PMID 1967982.
- "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell 60 (4): 547–55. Feb 1990. doi:10.1016/0092-8674(90)90658-2. PMID 1967983.
- "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Molecular and Cellular Biology 14 (6): 3938–48. Jun 1994. doi:10.1128/mcb.14.6.3938. PMID 7910944.
- "Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia". Proceedings of the National Academy of Sciences of the United States of America 90 (13): 6061–5. Jul 1993. doi:10.1073/pnas.90.13.6061. PMID 8327485. Bibcode: 1993PNAS...90.6061D.
- "Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex". Molecular and Cellular Biology 16 (4): 1632–40. Apr 1996. doi:10.1128/mcb.16.4.1632. PMID 8657138.
- "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal 17 (5): 1423–33. Mar 1998. doi:10.1093/emboj/17.5.1423. PMID 9482739.
- "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal 17 (5): 1434–45. Mar 1998. doi:10.1093/emboj/17.5.1434. PMID 9482740.
- "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell 96 (4): 587–97. Feb 1999. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460.
- "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. Apr 1999. doi:10.1128/MCB.19.4.3051. PMID 10082572.
- "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. Jul 1999. doi:10.1128/MCB.19.7.5134. PMID 10373562.
- "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Research 27 (18): 3752–61. Sep 1999. doi:10.1093/nar/27.18.3752. PMID 10471746.
- "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11464–9. Sep 1999. doi:10.1073/pnas.96.20.11464. PMID 10500199. Bibcode: 1999PNAS...9611464M.
- "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. Nov 1999. doi:10.1128/MCB.19.11.7577. PMID 10523646.
- "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". The Journal of Biological Chemistry 276 (6): 4109–18. Feb 2001. doi:10.1074/jbc.M008882200. PMID 11069920.
- "Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1518 (1–2): 215–20. Mar 2001. doi:10.1016/S0167-4781(01)00189-0. PMID 11267683. https://zenodo.org/record/1259885.
- "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex". The Journal of Biological Chemistry 276 (21): 17985–93. May 2001. doi:10.1074/jbc.M100678200. PMID 11279116.
- "A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program". The EMBO Journal 20 (7): 1739–53. Apr 2001. doi:10.1093/emboj/20.7.1739. PMID 11285237.
External links
- PBX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P40424 (Human Pre-B-cell leukemia transcription factor 1) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: P41778 (Mouse Pre-B-cell leukemia transcription factor 1) at the PDBe-KB.
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