Biology:PKNOX1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.

An important paralog of this gene is PKNOX2.

Function

PKNOX1 belongs to the three amino acid loop extension (TALE) class of homeodomain transcription factors that form transcriptionally active complexes involved in development and organogenesis. PKNOX1 is essential for embryogenesis, but it can also act as a tumor suppressor in adulthood.

Further reading

• "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma 39 (3–4): 241–56. October 2000. doi:10.3109/10428190009065824. PMID 11342305. 
• "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development 9 (6): 663–74. March 1995. doi:10.1101/gad.9.6.663. PMID 7729685. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549. 
• "Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers". The Journal of Biological Chemistry 272 (13): 8635–43. March 1997. doi:10.1074/jbc.272.13.8635. PMID 9079695. 
• "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3". Genomics 41 (2): 193–200. April 1997. doi:10.1006/geno.1997.4632. PMID 9143494. 
• "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene 15 (17): 2059–67. October 1997. doi:10.1038/sj.onc.1201367. PMID 9366523. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal 17 (5): 1423–33. March 1998. doi:10.1093/emboj/17.5.1423. PMID 9482739. 
• "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal 17 (5): 1434–45. March 1998. doi:10.1093/emboj/17.5.1434. PMID 9482740. 
• "A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1". The Journal of Biological Chemistry 273 (21): 13273–9. May 1998. doi:10.1074/jbc.273.21.13273. PMID 9582372. 
• "The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH". Genes & Development 13 (8): 946–53. April 1999. doi:10.1101/gad.13.8.946. PMID 10215622. 
• "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. July 1999. doi:10.1128/mcb.19.7.5134. PMID 10373562. 
• "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Research 27 (18): 3752–61. September 1999. doi:10.1093/nar/27.18.3752. PMID 10471746. 
• "Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation". Developmental Dynamics 218 (4): 636–47. August 2000. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I. PMID 10906782. 
• "PREP1, MEIS1 homolog protein, regulates PF4 gene expression". Biochemical and Biophysical Research Communications 305 (1): 155–9. May 2003. doi:10.1016/S0006-291X(03)00718-6. PMID 12732210. 

External links

• PKNOX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.