Biology:Nuclear receptor 4A3

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene.[1] NR4A3 is a member of the nuclear receptor family of intracellular transcription factors.

NR4A3 plays a central regulatory role in cell proliferation, differentiation, mitochondrial respiration,[2] metabolism[3][4] and apoptosis[5]

Interactions

NR4A3 has been shown to interact with SIX3.[6][7]

See also

References

  1. ↑ "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Molecular Endocrinology 9 (12): 1692–700. Dec 1995. doi:10.1210/mend.9.12.8614405. PMID 8614405. 
  2. ↑ "β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion". Am J Physiol Endocrinol Metab 311 (1): E186–201. July 2016. doi:10.1152/ajpendo.00022.2016. PMID 27221116. 
  3. ↑ "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. Nov 2006. doi:10.1210/en.2006-0447. PMID 16901967. 
  4. ↑ "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology 149 (6): 2853–65. Jun 2008. doi:10.1210/en.2007-1202. PMID 18325999. 
  5. ↑ "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation". The Journal of Biological Chemistry 281 (44): 33467–76. Nov 2006. doi:10.1074/jbc.M603436200. PMID 16945922. 
  6. ↑ "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Research 63 (2): 449–54. Jan 2003. PMID 12543801. 
  7. ↑ "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Developmental Neuroscience 23 (1): 17–24. 2001. doi:10.1159/000048692. PMID 11173923. 

Further reading

  • "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells". Biochemical and Biophysical Research Communications 205 (3): 1959–65. Dec 1994. doi:10.1006/bbrc.1994.2900. PMID 7811288. 
  • "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma". Oncogene 12 (2): 229–35. Jan 1996. PMID 8570200. 
  • "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation". Human Molecular Genetics 4 (12): 2219–26. Dec 1995. doi:10.1093/hmg/4.12.2219. PMID 8634690. 
  • "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1308 (3): 205–14. Sep 1996. doi:10.1016/0167-4781(96)00101-7. PMID 8809112. 
  • "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA". Gene 211 (1): 79–85. Apr 1998. doi:10.1016/S0378-1119(98)00095-X. PMID 9573341. 
  • "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator". Oncogene 18 (21): 3303–8. May 1999. doi:10.1038/sj.onc.1202675. PMID 10359536. 
  • "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11)". Oncogene 18 (52): 7594–8. Dec 1999. doi:10.1038/sj.onc.1203155. PMID 10602519. 
  • "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)". Cancer Research 60 (24): 6832–5. Dec 2000. PMID 11156374. 
  • "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arteriosclerosis, Thrombosis, and Vascular Biology 23 (11): 2002–7. Nov 2003. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795. 
  • "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB". Arteriosclerosis, Thrombosis, and Vascular Biology 24 (4): 697–702. Apr 2004. doi:10.1161/01.ATV.0000121570.00515.dc. PMID 14962944. 
  • "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes". Cancer Genetics and Cytogenetics 152 (2): 101–7. Jul 2004. doi:10.1016/j.cancergencyto.2003.11.011. PMID 15262426. 
  • "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1". Human Mutation 24 (6): 502–8. Dec 2004. doi:10.1002/humu.20102. PMID 15523651. 
  • "NOR-1 is involved in VEGF-induced endothelial cell growth". Atherosclerosis 184 (2): 276–82. Feb 2006. doi:10.1016/j.atherosclerosis.2005.04.008. PMID 15949808. 
  • "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli". The Journal of Biological Chemistry 280 (32): 29256–62. Aug 2005. doi:10.1074/jbc.M502606200. PMID 15964844. 
  • "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses". Arteriosclerosis, Thrombosis, and Vascular Biology 26 (10): 2288–94. Oct 2006. doi:10.1161/01.ATV.0000238346.84458.5d. PMID 16873729. 
  • "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. Nov 2006. doi:10.1210/en.2006-0447. PMID 16901967. 
  • "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology 149 (6): 2853–65. Jun 2008. doi:10.1210/en.2007-1202. PMID 18325999. 
  • "Neuron-derived orphan receptor 1 promotes proliferation of quiescent hepatocytes". Gastroenterology 144 (7): 1518–1529.e3. Jun 2013. doi:10.1053/j.gastro.2013.02.027. PMID 23462179. 

External links



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