Biology:ELF1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.

Function

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.

Further reading

• "Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1". Experimental Hematology 38 (9): 798–8, 808.e1-2. Sep 2010. doi:10.1016/j.exphem.2010.06.006. PMID 20600580. 
• "Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain". Journal of Immunology 168 (6): 2865–71. Mar 2002. doi:10.4049/jimmunol.168.6.2865. PMID 11884456. 
• "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology 19 (5): 3635–44. May 1999. doi:10.1128/mcb.19.5.3635. PMID 10207087. 
• "Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1". Bioscience, Biotechnology, and Biochemistry 64 (12): 2601–7. Dec 2000. doi:10.1271/bbb.64.2601. PMID 11210123. 
• "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular and Cellular Biology 12 (3): 1043–53. Mar 1992. doi:10.1128/mcb.12.3.1043. PMID 1545787. 
• "Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus". Annals of the New York Academy of Sciences 987: 240–5. Apr 2003. doi:10.1111/j.1749-6632.2003.tb06054.x. PMID 12727645. 
• "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry 210 (1–2): 131–42. Jul 2000. doi:10.1023/A:1007177623283. PMID 10976766. 
• "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians". American Journal of Human Genetics 92 (1): 41–51. Jan 2013. doi:10.1016/j.ajhg.2012.11.018. PMID 23273568. 
• "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". Journal of Virology 71 (5): 3563–73. May 1997. doi:10.1128/JVI.71.5.3563-3573.1997. PMID 9094628. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.