Biology:Transcription factor II F
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Short description: General transcription initiation factor
| general transcription factor IIF, polypeptide 1, 74kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2F1 |
| Alt. symbols | TFIIF, BTF4, RAP74 |
| NCBI gene | 2962 |
| HGNC | 4652 |
| OMIM | 189968 |
| RefSeq | NM_002096 |
| UniProt | P35269 |
| Other data | |
| Locus | Chr. 19 p13.3 |
| general transcription factor IIF, polypeptide 2, 30kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2F2 |
| Alt. symbols | TFIIF, BTF4, RAP30 |
| NCBI gene | 2963 |
| HGNC | 4653 |
| OMIM | 189969 |
| RefSeq | NM_004128 |
| UniProt | P13984 |
| Other data | |
| Locus | Chr. 13 q14 |
| general transcription factor IIF, polypeptide 2-like | |
|---|---|
| Identifiers | |
| Symbol | GTF2F2L |
| Alt. symbols | TFIIF |
| NCBI gene | 2964 |
| HGNC | 4654 |
| RefSeq | NG_003013 |
| Other data | |
| Locus | Chr. 4 q31.22 |
Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1][2][3]
TFIIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.[4][5][6]
TFIIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.
See also
References
- ↑ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
- ↑ "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. 2000. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
- ↑ "Trajectory of DNA in the RNA polymerase II transcription preinitiation complex". Proc Natl Acad Sci USA 94 (23): 12268–73. 1997. doi:10.1073/pnas.94.23.12268. PMID 9356438. Bibcode: 1997PNAS...9412268K.
- ↑ "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature 355 (6359): 464–7. 1992. doi:10.1038/355464a0. PMID 1734284. Bibcode: 1992Natur.355..464F.
- ↑ "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. 1994. doi:10.1093/hmg/3.1.61. PMID 8162052.
- ↑ "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1–2): 75–80. 1995. doi:10.1159/000133942. PMID 7835093.
External links
- Transcription+Factor+TFIIF at the US National Library of Medicine Medical Subject Headings (MeSH)
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