Chemistry:MDPHP

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Short description: Chemical compound
3',4'-Methylenedioxy-α-pyrrolidinohexiophenone
MDPHP.svg
3',4'-Methylenedioxy-α-pyrrolidinohexiophenone.png
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H23NO3
Molar mass289.375 g·mol−1
3D model (JSmol)

MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s,[1] which has been reported as a novel designer drug. In the UK its slang name is monkey dust.[2][3] It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.[4][5][6][7]

Legal status

MDPHP is specifically listed as a controlled substance in Japan [8] and Hungary,[9] and is controlled under analogue provisions in a number of other jurisdictions.

Documented fatalities

A case of a "fatal acute intoxication caused by MDPHP" in a 48 year old male was reported in February 2022 by physicians at an Italian hospital.[10]

See also

References

  1. Koeppe H, Zeile K, Ludwig G, "Patent DE - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe", DE patent 1545591, issued 28 May 1965
  2. "Monkey Dust drug use 'an epidemic', emergency workers warn". BBC. 10 August 2018. https://www.bbc.com/news/uk-england-stoke-staffordshire-45144531. 
  3. Roberts M. Monkey dust drug clampdown could be coming in UK. BBC News, 11 May 2023
  4. "Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: A review of their pharmacology, acute toxicity, and metabolism". Forensic Toxicology 32: 1–8. 2013. doi:10.1007/s11419-013-0218-1. 
  5. "Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market.". Forensic Toxicology 34 (1): 108–14. January 2016. doi:10.1007/s11419-015-0293-6. 
  6. "Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats". Clinical Toxicology (Philadelphia, Pa.) 56 (4): 256–263. April 2018. doi:10.1080/15563650.2017.1370097. PMID 28895757. 
  7. "Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time-high resolution mass spectrometry-derived "neutral loss" spectra". Talanta 179: 546–553. March 2018. doi:10.1016/j.talanta.2017.11.020. PMID 29310273. 
  8. "指定薬物名称・構造式一覧(平成27年9月16日現在)" (in Japanese). 厚生労働省 (Ministry of Health, Labour and Welfare). 16 September 2015. http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf. 
  9. "A Daath.hu kiegészítése a BSZKI "designer jogi listáján" nem szereplő, de a C-lista 1.-4. szerkezeti leírásainak megfelelő, illetve a C-lista 5. felsorolásában szereplő néhány anyagról" (in Hungarian). http://www.daath.hu/incoming/designer_jogi_lista_20150903_BSZKI_Daath_kieg.pdf. 
  10. "A unique case of death by MDPHP with no other co-ingestion: a forensic toxicology case". International Journal of Legal Medicine 136 (5): 1291–1296. September 2022. doi:10.1007/s00414-022-02799-w. PMID 35169902.